Nghiên cứu tác dụng cầm máu và độ an toàn của công thức bào chế viên nang cao bẹ Móc trên thực nghiệm

Tóm tắt

The purpose of this research was to evaluate the hemostatic effect and safety of the formulation from Caryota mitis collar extract in animal. The pharmacological actions and the toxicological effect of the formulation were investigated using the subaqueous tail bleeding time in rats; blood-clotting time in rabbits; oral acute toxicity in mice and 28 days oral repeated doses in rats. On oral administration with the dose of 360 mg/kg and 540 mg/kg in rats, the formulation produced significant decrease in bleeding time with the reduction rate 42.7% and 39,4% respectively. The formulation did not show any significant changes in clotting time in rabbits with the dose of 180 mg/kg and 270 mg/kg. In the acute oral toxicity test, a maximal dose of 20 g/kg was not lethal to the mice and did not cause any manifestations of toxicity. Repeated doses (350 mg/kg and 1050 mg/kg/day) for 28 days in rats did not appear to affect the general condition parameters, body weight, hematopoietic function, kidney function. The raises of AST and ALT in higher dose (1050 mg/kg) female rats had recovered to normal levels after 14 days of discontinuing. The Caryota mitis collar extract capsules have hemostatic activity without significant change in blood coagulation. Acute and sub-chronic toxicological properties provide safety profile for the development of the hemostatic fomulation.