Synthesis and cytotoxic evaluation of amide derivatives of gambogic acid

Thi Minh Nguyet Hoang, Thi Thuy Huong Le, Lan Phuong Doan, Thi Thu Huong Trinh, Quoc Long Pham, Huu Nghi Do, Thi Thu Thuy Tran, Pham Minh Quan
Cơ quan, tổ chức của tác giả

Các tác giả

  • Thi Minh Nguyet Hoang Institute of Chemistry, Vietnam Academy of Science and Technology
  • Thi Thuy Huong Le Institute of Chemistry, Vietnam Academy of Science and Technology
  • Lan Phuong Doan Institute of Chemistry, Vietnam Academy of Science and Technology
  • Thi Thu Huong Trinh Institute of Chemistry, Vietnam Academy of Science and Technology
  • Quoc Long Pham Ton Duc Thang University
  • Huu Nghi Do Institute of Chemistry, Vietnam Academy of Science and Technology
  • Thi Thu Thuy Tran Institute of Chemistry, Vietnam Academy of Science and Technology
  • Pham Minh Quan

DOI:

https://doi.org/10.59882/1859-364X/375

Tóm tắt

A series of amide derivatives (3a–3h) were synthesized by coupling gambogic acid with various amines under mild PyBOP/DIPEA-mediated conditions. The cytotoxic activities of these derivatives were evaluated against HGC-27 (gastric carcinoma), Hep-G2 (hepatocellular carcinoma), and Vero (normal kidney) cell lines using the MTT assay. Several derivatives demonstrated enhanced cytotoxicity compared to GA, particularly compounds 3h, 3f, and 3b, which showed IC₅₀ values of 11.63, 12.84, and 13.82 µM, respectively, against HGC-27 cells.

Tải xuống

Đã Xuất bản

23-12-2025

Cách trích dẫn

Hoang, T. M. N., Le, T. T. H., Doan, L. P., Trinh, T. T. H., Pham, Q. L., Do, H. N., Tran, T. T. T., & Pham Minh Quan. (2025). Synthesis and cytotoxic evaluation of amide derivatives of gambogic acid. Tạp Chí Nghiên cứu Dược Và Thông Tin Thuốc, 27. https://doi.org/10.59882/1859-364X/375

Số

T. 27 (2025): Tạp chí Nghiên cứu Dược và Thông tin thuốc

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